Adult trials
- SCANALL: Study of Nordic CML and ALL Patients using Next Generation Sequencing Analysis for Low Level Mutations
- EWALL-PH-03: An open label, 3-arm, randomised phase II study to compare the safety and efficacy of ponatinib in combination with either chemotherapy or blinatumomab with imatinib plus chemotherapy as front-line therapy for patients aged 55 years and over with Philadelphia chromosome-positive (Ph+ or BCR-ABL+) acute lymphoblastic leukemia (ALL)
- ALLTogether: A Treatment study protocol of the ALLTogether Consortium for children and young adults (1-45 years of age) with newly diagnosed acute lymphoblastic leukaemia (ALL)
- Ponatinib-3001:A phase 3, randomized, open-label, multicenter study comparing ponatinib versus imatinib, administered in combination with reduced-intensity chemotherapy, in patients with newly diagnosed philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL)
- EWALL-INO: A Phase 2 Study of Inotuzumab Ozogamicin (INO) Combined to Chemotherapy in Older Patients with Philadelphia Chromosomenegative CD22+ B-cell Precursor Acute Lymphoblastic Leukemia
- CHDM201H12101C: A phase Ib, multi-arm, open-label, study of HDM201 in combination with MBG453 or venetoclax in adult subjects with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS)
- HO150, AMLSG 29-18: A phase 3, multicenter, double-blind, randomized, placebo-controlled study of ivosidenib or enasidenib in combination with induction therapy and consolidation therapy followed by maintenance therapy in patients with newly diagnosed acute myeloid leukemia or myelodysplastic syndrome with excess blasts-2, with an IDH1 or IDH2 mutation, respectively, eligible for intensive chemotherapy
- VenEx, FLG-V001: Two-stage, two-arm, open-label phase II study of venetoclax in combination with azacitidine in acute myeloid leukemia patients selected using ex vivo drug sensitivity screening
- HO156, AMLSG 28-18: A phase 3, multicenter, open-label, randomized study with gilteritinib or midostaurine in combination with induction and consolidation chemotherapy followed by 1 year of maintenance treatment in patients with newly diagnosed acute myeloid leukaemia (AML) or myelodysplastic syndromes with excess blasts (MDS-EB2) with FLT3 mutations who are eligible for intensive chemotherapy
- CA209-7FL: A Randomized, Multicenter, Double-blind, Placebo-controlled Phase 3 Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in the Treatment of High-risk, Stage II-III Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Breast Cancer
- AMEERA: A randomized, multicenter, double-blind phase 3 study of SAR439859 plus Palbociclib versus Letrozole plus Palbociclib for the treatment of patients with ER (+), HER2 (-) breast cancer who have not received prior systemic anti-cancer treatment for advanced disease
- BORI: An open label, phase Ib, dose-escalation study evaluating the safety and tolerability of xentuzumab and abemaciclib in patients with locally advanced or metastatic solid tumors and in combination with endocrine therapy in patient with locally advenced or metastatic hormone receptor HER2-, breast cancer, followed by expansion cohorts
- STESIDES: Open, non-randomised, uncontrolled, multicenter dose-escalation, firts-in-human study with a dose expansion. Safety and pharmacokinetics of ODM-209 in patients with metastatic castration-resistant prostate cancer or estrogen receptor- positive, HER2 negative advanced breast cancer
- BOLD: A randomized phase III study comparing trastuzumab, pertuzumab plus docetaxel (TPD) followed by 3 cycles of chemotherapy to the current standard regimen as the treatments of early HER2-positive breast cancer
- IMPASSION: A phase III, randomized, double-blind, placebo-controlled, multicentre study of the efficacy and safety of atezolizumab plus chemotherapy for patients with early relapsing recurrent (inoperable locally advanced or metastatic) triple-negative breast cancer
- BOLD: A Randomized Phase III Study Comparing Trastuzumab, Pertuzumab plus Docetaxel ( TPD) Followed by 3 Cycles of Chemotherapy to the Current Standard Regimen as the Treatments of Early HER2-positive Breast Cancer
- CLL17: A phase 3 multicentre, randomized, prospective, open-label trial of Ibrutinib monotherapy versus fixed-duration Venetoclax plus Obinutuzumab versus fixed-duration Venetoclax plus Ibrutinib in patients with previously untreated chronic lymphocytic leukaemia (CLL)
- ASSURE: A Phase 3b, Multicenter, Open-Label, Single-Arm Study of Acalabrutinib (ACP-196) in Subjects with Chronic Lymphocytic Leukemia
- CJBH492A12101: A phase I/Ib open-label, multi-center dose escalation study of JBH492 in patients with relapsed/refractory chronic lymphocytic leukemia (CLL) and Non-Hodgkin´s Lymphoma (NHL)
- The stop-GIST-Trial: Discontinuation of imatinib in patients with oligo-metastatic gastrointestinal stromal tumor that has become radiologically undetectable with treatment. A prospective multicenter phase II trial
- SSGXXII: A randomized phase II trial of imatinib alternating with regorafenib compared to imatinib alone for the first line treatment of advanced gastrointestinal stromal tumor (GIST)
- MK6482-005: An Open-label , Randomized Phase 3 study of MK-6482 Versus Everolimus in participants with advanced renall cell carcinoma that has progressed after prior PD1/ L1 and VEGF-targeted therapies
- COSMIC XL184-313: A Randomized, Double-Blind, Controlled Phase 3 Study of Cabozantinib in Combination with Nivolumab and Ipilimumab versus Nivolumab and Ipilimumab in Subjects with Previously Untreated Advanced or Metastatic Renal Cell Carcinoma of Intermediate or Poor Risk
- BLU-667: A Randomized, Open-Label, Phase 3 Study of Pralsetinib versus Standard of Care for First Line Treatment of RET fusion-positive, Metastatic Non-Small Cell Lung Cancer
- SPARTA: Phase 1 / 2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
- CODEBREAK: A Phase 3 Multicenter, Randomized, Open Label, Active-controlled, Study of AMG 510 Versus Docetaxel for the Treatment of Previously Treated Locally Advanced and Unresectable or Metastatic NSCLC Subjects With Mutated KRAS p.G12C
- THORIUM PSMA: An open-label, firts-in-human, multi-center study to evaluate the safety, tolerability, pharmocokinetics and anti-tumor activity of thorium-227 labeled antibody-chelator conjugate, BAY 2287411 injection, in patients with solid tumors known to express mesothelin
- NP30179: A Multicenter, open-label, phase I study to evaluate the safety, tolerability and pharmacokinetics of escalating doses of RO7082859 as a single agent and in combination with obinutuzumab administered after a fixed, single dose pre-treatment of obinutuzumab ( Gazyva/ Gazyvaro ) in patient with relapsed / refractory B-cell Non Hodgin`s Lymphoma
- ENRICH: Randomised, open label study of Rituximab / Ibrutinib vs Rituximab / Chemotherapy in older patients with untreated mantle cell lymphoma
- VALERIA: Venetoclax, Lenalidomide and Rituximab in Patients With Relapsed/Refractory Mantle Cell Lymphoma
- CJBH492A12101: A phase I/Ib Open-label, Multi-center Dose Escalation Study of JBH492 in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin’s Lymphoma (NHL)
- JCAR: A phase 2, single-arm, multi-cohort, multi-center trial to determine the efficacy and safety of JCAR017 in adult subjects with aggressive B-cell Non-Hodgkin lymphoma
- LYMRIT: A phase I/II study of lutetium (177Lu)-lilotomab satetraxetan (Betalutin®) antibody-radionuclide-conjugate for treatment of relapsed non-Hodgkin lymphoma
- POLAR BEAR: R-MINI-CHOP versus R-MINI-CHP in combination with polatuzumab-vedotin, as primary treatment for patients with diffuse large B-cell lymphoma, >80 years, or fail >75 years - an open label randomized Nordic Lymphoma group. Phase III trial- NLG-LBC7
- SEACAP: The effect of seasonal prophylactic influenza vaccination and factors influencing the patients' immune-competence during anti-PD-1 treatment of patients with melanoma
- CA022-001: Phase 1/2a First-In-Human Study of BMS-986218 Monoclonal Antibody Alone and in Combination with Nivolumab in Advanced Solid Tumors
- CA030-001: A Phase 1/2 First-in-Human Study of BMS-986249 Alone and in Combination with Nivolumab in Advanced Solid Tumors
- LAG (CA224-020): A Phase 1/2a Dose Escalation and Cohort Expansion Study of the Safety, Tolerability, and Efficacy of Anti-LAG-3 Monoclonal Antibody (BMS-986016) Administered Alone and in Combination with Anti-PD-1 Monoclonal Antibody (Nivolumab, BMS-936558) in Advanced Solid Tumors
- CA209-76K: A Phase III randomized, double-blind study of adjuvant immunotherapy with nivolumab versus placebo after complete resection of tage IIB/ C melanoma
- F59009, ENHANCE: A Randomized, Double-blind, Multicenter Study Comparing Magrolimab in Combination with Azacitidine versus Azacitidine Plus Placebo in Treatment-naïve Patients with Higher Risk Myelodysplastic Syndrome
- STIMULUS, CMBG453B12301: A randomized, double-blind, placebo-controlled phase III multi-center study of azacitidine with or without MBG453 for the treatment of patients with intermediate, high or very high risk myelodysplastic syndrome (MDS) as per IPSS-R, or Chronic Myelomonocytic Leukemia-2 (CMML-2)
- INCB 50465-313: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Combination of PI3Kδ Inhibitor Parsaclisib and Ruxolitinib in Participants with Myelofibrosis
- INCB 50465-304: A Randomized, Double-Blind, Placebo-Controlled Study of the PI3Kδ Inhibitor Parsaclisib Plus Ruxolitinib in Participants with Myelofibrosis Who Have Suboptimal Response to Ruxolitinib
- INCB 57643-103: A Phase 1, Open-Label, Safety and Tolerability Study of INCB057643 in Participants with Myelofibrosis
- OP108, LIGHTHOUSE: A Randomized, Controlled, Open-Label Phase 3 Study of Melflufen in combination with Daratumumab Compared with Daratumumab in Patients with Relapsed or Relapsed-Refractory Multiple Myeloma
- CC-92480-MM-001: A Phase 1/2 Multicenter, Open-label Study to Assess the Safety, Pharmacokinetics and Efficacy of CC-92480 monotherapy and in Combination with Dexamethasone in Subjects with Relapsed and Refractory Multiple Myeloma
- ARROW2: A Randomized, Open-label, Phase 3 Study Comparing Once-weekly vs Twice-weekly Carfilzomib in Combination with Lenalidomide and Dexamethasone in Subjects with Relapsed or Refractory Multiple Myeloma (A.R.R.O.W.2)
- KEYNOTE-991: A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Plus ADT Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
- BAYER20511: Open-label, Non-randomized Phase 1, Multicenter Study to Assess Radium- 223 Biodistribution in Participants With Bone Metastatic Castration Resistant Prostate Cancer (CRPC) Receiving Radium-223 Dichloride Treatment
- CYPIDES: Safety and pharmacokinetics of ODM-208 in patients with metastatic castration-resistant prostate cancer
- HERO: Randomized, open-label, parallel group efficacy and safety study to evaluate oral daily relugolix 120 mg to Leuprolide in patients with androgen-sensitive advanced prostate
- THORIUM PSMA: A Phase 1, open label, first in human, multi center, study to evaluate the safety, tolerability, pharmacokinetics and anti tumor activity of a thorium-227 labeled antibody-chelator conjugate BAY 2315497 injection, in patient with metastatic castration resistent prostate cancer
- ProScreen: A Randomized Trial of Early Detection of Clinically Significant Prostate Cancer
- PRIAS: Prostate cancer Research International: Active Surveillance - guideline and study for the expectant management of localized prostate cancer with curative intent
- SPCG-15: Primary Radical Prostatectomy Versus Primary Radiotherapy for Locally Advanced Prostate Cancer: an Open Randomized Clinical Trial
- RAMPP: Multicentric, Prospective, Randomized Controlled Trial Comparing Best Systemic Therapy (BST) With Radical Prostatectomy or BST Alone in the Management of Men With Pauci-metastatic Prostate Cancer
- STESIDES: Open, non-randomised, uncontrolled, multicenter dose-escalation, firts-in-human study with a dose expansion. Safety and pharmacokinetics of ODM-209 in patients with matastatic castration-resostant prostate cancer or estrogen receptor- positive, HER2 negative advanced breast cancer
Pediatric trials
- LELU-study: Skeletal complications in childhood leukemia - tissue-level mechanisms
- IntreALL SR 2010: International Study for Treatment of Standard Risk Childhood Relapsed ALL 2010
- IntreALL HR 2010: International Study for Treatment of High Risk Childhood Relapsed ALL 2010
- LELU-study: Skeletal complications in childhood leukemia - tissue-level mechanisms
- BRIGATINIB: A Phase I/II study of Brigatinib as monotherapy in pediatric and young adult patients with ALK-positive Anaplastic Large Cell Lymphoma (ALCL), Inflammatory Myofibroblastic Tumors (IMT) or other solid tumors
- ITCC-059: A phase I/II study of Inotuzumab Ozogamicin as a single agent and in combination with chemotherapy for pediatric Cd22 positive relapsed ALL
- CASSIOPEIA: A Phase II Trial of Tisagenlecleucel in First-line High-risk (HR) Pediatric and Young Adult Patients With B-cell Acute Lymphoblastic Leukemia (B-ALL) Who Are Minimal Residual Disease (MRD) Positive at the End of Consolidation (EOC) Therapy
- EsPhALL2017/COGAALL1631: International phase III trial in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) testing imatinib in combination with two different cytotoxic chemotherapy backbones
- (SIOP CNS GCT II): Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors (SIOPCNSGCTII)
- SIOP EPENDYMOMA: An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma (SIOP-EP-II)
- (SIOP) PNET 5 Medulloblastooma: An international prospective study on clinically standard-risk Medulloblastoma in children older than 3 to 5 years with low-risk biological profile (PNET 5 MB - LR) or average-risk biological profile (PNET 5 MB -SR), SIOP PNET 5 Medulloblastoma
- EuroNet-PHL C2 (opening soon) Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents
- LBL 2018: International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma (LBL 2018)
- B-NHL 2013 2.2: Treatment protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents (B-NHL 2013)
- BAY27257556 (will be opening in autumn 2021): PrOspective Non-interventional Study in Patients With Locally Advanced or Metastatic TRK Fusion Cancer Treated With Larotrectinib
- INFORM: INdividualized Therapy FOr Relapsed Malignancies in Childhood
- iCAN-PEDI
- SIOP Umbrella 2016 (will be opening)
- PHITT: Paediatric Hepatic International Tumour Trial (PHITT)
- High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN) (HR-NBL2) (will be opening)
HUS Helsinki University Central Hospital, Comprehensive Cancer Center: haluantutkimuspotilaaksi@hus.fi
HUS Helsinki University Hospital, New Chidren’s Hospital: Clinical Trial Unit (CTU) of the new Children´s Hospital
Participation in medical research
In accordance with Finnish treatment practice, we need a referral from the attending physician to participate in the study. We also get the necessary information about the suitability for the study from the attending physician.
