The following trials are currently enrolling patients:


Epithelial ovarian cancer

A randomized, double-blind, phase 3 comparison of platinum-based therapy with TSR-042 and niraparib versus standard care platinum-based therapy as first-line treatment of stage III or IV nonmucinous epithelial ovarian cancer.

Principal investigator: Loukovaara Mikko
HUS Helsinki University Hospital, Department of Obstetrics and Gynecology
email: mikko.loukovaara@hus.fi


Prostate cancer

STESIDES: Open, non-randomised, uncontrolled, multicenter dose-escalation, firts-in-human study with a dose expansion. Safety and pharmacokinetics of ODM-209 in patients with matastatic castration-resostant prostate cancer or estrogen receptor- positive, HER2 negative advanced breast cancer.

Principal investigator: Utriainen Tapio
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


CYPIDES: Safety and pharmacokinetics of ODM-208 in patients with metastatic castration-resistant prostate cancer.

Principal investigator: Utriainen Tapio
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


THORIUM PSMA: A Phase 1, open label, first in human, multi center, study to evaluate the safety, tolerability, pharmacokinetics and anti tumor activity of a thorium-227 labeled antibody-chelator conjugate BAY 2315497 injection, in patient with metastatic castration resistent prostate cancer

Principal investigator: Vaalavirta Leila
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


HERO: Randomized, open-label, parallel group efficacy and safety study to evaluate oral daily relugolix 120 mg to Leuprolide in patients with androgen-sensitive advanced prostate

Principal investigator: Taari Kimmo
HUS Helsinki University Hospital, Abdominal Center, Urology
Contact information: Study nurse +358 50 247 1345


LIDDS: A Single Blind, Two-Stage Dose Finding Study to Evaluate the Safety, Tolerability and Efficacy of a Single Liproca® Depot Injection into the Prostate in Patients with Localized Prostate Cancer, Assigned to Active Surveillance who are at High Risk for Disease Progression (followed by an Open Label Extension with a Repeat Injection (Optional)

Principal investigator: Antti Rannikko
HUS Helsinki University Hospital, Abdominal Center, Urology
Contact information: Study nurse + 358 50 247 1345


ProScreen: A Randomized Trial of Early Detection of Clinically Significant Prostate Cancer (ProScreen)

Principal investigator: Antti Rannikko
HUS Helsinki University Hospital, Abdominal Center, Urology
Contact information: Study nurse + 358 50 247 1345


PRIAS: Prostate cancer Research International: Active Surveillance – guideline and study for the expectant management of localized prostate cancer with curative intent

Principal investigator: Antti Rannikko
HUS Helsinki University Hospital, Abdominal Center, Urology
Contact information: Study nurse +358 50 247 1345


SPCG-15: Primary Radical Prostatectomy Versus Primary Radiotherapy for Locally Advanced Prostate Cancer: an Open Randomized Clinical Trial

Principal investigator: Antti Rannikko
HUS Helsinki University Hospital, Abdominal Center, Urology
Contact information: Study nurse +358 50 247 1345


RAMPP: Multicentric, Prospective, Randomized Controlled Trial Comparing Best Systemic Therapy (BST) With Radical Prostatectomy or BST Alone in the Management of Men With Pauci-metastatic Prostate Cancer

Principal investigator: Antti Rannikko
HUS Helsinki University Hospital, Abdominal Center, Urology
Contact information: Study nurse +358 50 247 1345


DEDUCER: Development of Diagnostics and Treatment of Urological Cancers

Principal investigator: Antti Rannikko
HUS Helsinki University Hospital, Abdominal Center, Urology
Contact information: Study nurse +358 50 247 1345


FinnBladder 9: Treatment of Ta Bladder Cancer in High Risk of Recurrence – Fluorescence Cystoscopy With Optimized Adjuvant Mitomycin-C

Principal investigator: Riikka Järvinen
HUS Helsinki University Hospital, Abdominal Center, Urology
Contact information: Study nurse +358 50 247 1345


GIST ( Gastro Intestinal Stromal Tumor)

The stop-GIST-Trial: Discontinuation of imatinib in patients with oligo-metastatic gastrointestinal stromal tumor that has become radiologically undetectable with treatment. A prospective multicenter phase II trial

Principal investigator: Katriina Peltola
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


SSGXXII: A randomized phase II trial of imatinib alternating with regorafenib compared to imatinib alone for the first line treatment of advanced gastrointestinal stromal tumor (GIST)

Principal investigator: Katriina Peltola
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


Cholangiocarcinoma

FIGHT-302: A phase 3, open-label, randomized, active-controlled, multicenter study to evaluate the efficacy and safety og pemigatinib versus cemsitabine plus cisplatin chemotherapy in firts-line threatment of participants with unresectable or metastatic cholangiocarcinoma with FGFR2 rearrangement FIGHT-302

Principal investigator: Katriina Peltola
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


Solid tumor

 MATINS: A Study to Evaluate Safety, Tolerability and Preliminary Efficacy of FP-1305 in Cancer Patients

Principal investigator: Annika Pasanen
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


Origin of tumour unknown (NUD)

CUPISCO: A phase II, randomized, active-controlled, multi-center study comparing the efficacy and safety of targeted therapy or cancer immunotherapy guided by genomic profiling versus platinum-based chemotherapy in patients with cancer of unknown primary site who have received three cycles of platinum douplet chemotherapy

Principal investigator: Pia Suonpää
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


Lung cancer

THORIUM: An open-label, firts-in-human, multi-center study to evaluate the safety, tolerability, pharmocokinetics and anti-tumor activity of thorium-227 labeled antibody-chelator conjugate, BAY 2287411 injection, in patients with solid tumors known to express mesothelin

Principal investigator: Vaalavirta Leila
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


Lymphoma

ENRICH: Randomized, open label study of Rituximab / Ibrutinib vs Rituximab / Chemotherapy in older patients with untreated mantel cell lymphoma.

Principal investigator: Annika Pasanen
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


NP30179: A Multicenter, open-label, phase I study to evaluate the safety, tolerability and pharmacokinetics of
escalating doses of RO7082859 as a single agent and in combination with obinutuzumab administered
after a fixed, single dose pre-treatment of obinutuzumab ( Gazyva/ Gazyvaro ) in patient with relapsed /
refractory B-cell Non Hodgin`s Lymphoma.

Principal investigator: Sirpa Leppä
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi

BIO-CHIC: Biomarker driven and dose intensified chemoimmunotherapy with early CNS prophylaxis in patients less than 65 years with high risk diffuse large B-cell lymphoma

Principal investigator: Sirpa Leppä
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


PREBEN: A phase 1/2 study of combination of pixantrone, etoposide, bendamustine and in CD-20 positive tumors, rituximab in patients with relapsed aggressive non-Hodgkin lymphomas of B- or T- cell phenotype- The PREBEN study

Principal investigator: Sirpa Leppä
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


CHRONOS-4: A phase III, randomized, double-blind, controlled, multicenter study of intravenous PI3K inhibitor copanlisib in combination with standard immunochemotherapy versus standard immunochemotherapy in patients with relapsed indolent non-Hodgkin’s lymphoma (iNHL)- CHRonos-4

Principal investigator: Sirpa Leppä
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


JCAR: A phase 2, single-arm, multi-cohort, multi-center trial to determine the efficacy and safety of JCAR017 in adult subjects with aggressive B-cell Non-Hodgkin lymphoma

Principal investigator: Sirpa Leppä
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


LYMRIT: A phase I/II study of lutetium (177Lu)-lilotomab satetraxetan (Betalutin®) antibody-radionuclide-conjugate for treatment of relapsed non-Hodgkin lymphoma.

Principal investigator: Sirpa Leppä
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


TRIANGLE: Autologous Transplantation after rituximab/Ibrutinib/Ara-c containig induction generalized mantle cell lymphoma- a randomized European mcl network trial

Principal investigator: Sirpa Leppä
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


SAKK 35/14: Rituximab with or without Ibrutinib for untreated patients with advanced follicular lymphoma in need of therapy. A randomized, double-blinded, SAKK and NLGcollaborative Phase II trial.

Principal investigator: Micaela Hernberg
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


Kidney cancer

COSMIC XL184-313: A Randomized, Double-Blind, Controlled Phase 3 Study of Cabozantinib in Combination with Nivolumab
and Ipilimumab versus Nivolumab and Ipilimumab in Subjects with Previously
Untreated Advanced or Metastatic Renal Cell Carcinoma of Intermediate or Poor Risk.

Principal investigator: Katriina Peltola
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


Melanoma

CA224-047: A randomized, douple-blind, phase 2/3 study of relatlimab combined with nivolumab versus nivolumab
in participants with previously untreated metastatic or unresectable melanoma.

Principal investigator: Micaela Hernberg
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


CA224-020: A Phase 1/2a Dose Escalation and Cohort Expansion Study of the Safety, Tolerability, and Efficacy of Anti-LAG-3 Monoclonal Antibody (BMS-986016)
Administered Alone and in Combination with Anti-PD-1 Monoclonal Antibody (Nivolumab, BMS-936558) in Advanced Solid Tumors

Principal investigator: Katriina Peltola
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


CA209-76K: A Phase III randomized, double-blind study of adjuvant immunotherapy with nivolumab versus
placebo after complete resection of tage IIB/ C melanoma

Principal investigator:
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


Breast cancer

BORI: An open label, phase Ib, dose-escalation study evaluating the safety and tolerability of xentuzumab and abemaciclib in patients with locally advanced or metastatic solid tumors and in combination with endocrine therapy in patient with locally advenced or metastatic hormone receptor HER2-, breast cancer, followed by expansion cohorts.

Principal investigator: Meri Utriainen
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


STESIDES: Open, non-randomised, uncontrolled, multicenter dose-escalation, firts-in-human study with a dose expansion. Safety and pharmacokinetics of ODM-209 in patients with matastatic castration-resostant prostate cancer or estrogen receptor- positive, HER2 negative advanced breast cancer

Principal investigator: Tapio Utriainen
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


CLEE011A2207: A phase II, multicenter, randomized, open-label study to evaluate the safety and efficacy of 400mg of ribociclib in combination with non-steroidal aromatase inhibitors for the treatment of pre- and postmenopausal women with hormone receptor-positive, HER2 negative advanced breast cancer who received no prior therapy for advanced  disease

Principal investigator: Tytti Ahola
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


BOLD: A randomized phase III study comparing trastuzumab, pertuzumab plus docetaxel (TPD) followed by 3 cycles of chemotherapy to the current standard regimen as the treatments of early HER2-positive breast cancer.

Principal investigator: Heikki Joensuu
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


IMPASSION: A phase III, randomized, double-blind, placebo-controlled, multicentre study of the efficacy and safety of atezolizumab plus chemotherapy for patients with early relapsing recurrent (inoperable locally advanced or metastatic) triple-negative breast cancer

Principal investigator: Meri Utriainen
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center
email: haluantutkimuspotilaaksi@hus.fi


A Randomized, Open-Label, Phase 3 Study of Abemaciclib combined with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone in Patients with High Risk, Node Positive, Early Stage,Hormone Receptor Positive,Human Epidermal Receptor 2 Negative, Breast Cancer

Principal investigator: Paul Nyandoto
Päijät-Häme Central Hospital, oncology outpatient clinic, Lahti
Contact information:  +358 3 819 4741 (study nurse)


BOLD: A Randomized Phase III Study Comparing Trastuzumab, Pertuzumab plus Docetaxel ( TPD) Followed by 3 Cycles of Chemotherapy to the Current Standard Regimen as the Treatments of Early HER2-positive Breast Cancer

Päätutkija: Paul Nyandoto
Päijät-Häme Central Hospital, oncology outpatient clinic, Lahti
Contact information:  +358 3 819 4741 (study nurse)


Colorectal cancer

No studies recruiting patients are currently ongoing for colorectal cancer


ALL – Acute lymphatic leukemia


ALLTogether: Treatment Protocol for 18-45 years of age with Acute Lymphoblastic Leukemia patients. Same treatment protocol for 1-17 years of age patients.

Not yet active, not yet recruiting.

Principal investigator: Ulla Wartiovaara-Kautto
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center

Ponatinib-3001: An Efficacy Study Comparing Ponatinib Versus Imatinib, Administered in Combination With Reduced-Intensity Chemotherapy, in Participants With Newly Diagnosed Ph+ ALL.

Principal investigator: Kimmo Porkka
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


EWALL-INO: Study of Inotuzumab Ozogamicin (INO) Combined to Chemotherapy in Older Patients with Philadelphia Chromosomenegative CD22+ B-cell Precursor Acute Lymphoblastic Leukemia.

Principal investigator: Ulla Wartiovaara-Kautto
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


T-PLL – T-cell Prolymphocytic Leukemia

M18-803: Open-Label Study Evaluating the Efficacy of Venetoclax Plus Ibrutinib in Subjects with T-Cell Prolymphocytic Leukemia.

Principal investigator: Mikko Keränen
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


AML – Acute myeloid leukemia

CHDM201H12101C: Open-label study of HDM201 in combination with MBG453 or venetoclax in adult subjects with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS).

Principal investigator: Kimmo Porkka
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


CPDR001X2105: Open-label study of PDR001 and/or MBG453 in combination with decitabine in patients with acute myeloid leukemia or high risk myelodysplastic syndrome.

Principal investigator: Kimmo Porkka
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


DCOne-002, Advance II: An international, Multicentre, Open-label Study to Evaluate The Efficacy and Safety of Two Different Vaccination Regimens of Immunotherapy with Allogeneic Dendritic Cells, DCP-001, in Patients with Acute Myeloid Leukemia that are In Remission with Persistent MRD.

Principal investigator: Kimmo Porkka
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


DS303-A-U105: A Phase 1 Study of Milademetan in Combination With Quizartinib in Subjects With FLT3-ITD Mutant Acute Myeloid Leukemia That Are Relapsed/Refractory, or Newly Diagnosed and Unfit for Intensive Chemotherapy

Not yet active, not yet recruiting.

Principal investigator: Mika Kontro
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


HO150, AMLSG 29-18: Open, multicenter, double-blind, randomized, placebo-controlled study of ivosidenib or enasidenib in combination with induction therapy and consolidation therapy followed by maintenance therapy in patients with newly diagnosed acute myeloid leukemia or myelodysplastic syndrome with excess blasts-2, with an IDH1 or IDH2 mutation, respectively, eligible for intensive chemotherapy.

Principal investigator: Mika Kontro
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


VenEx, FLG-V001: Open-Label Study of Venetoclax in Combination With Azacytidine in Acute Myeloid Leukemia Patients Selected Using Ex Vivo Drug Sensitivity Screening.

Principal investigator: Mika Kontro
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


CML – Chronic myeloid leukemia


BosuPeg (NordCML012) (Nordic CML Study Group) Phase III: Long-acting low dose Ropeginterferon in patients with chronic myeloid leukemia treated with Bosutinib from diagnosis.

Principal investigator: Perttu Koskenvesa
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center

DASTOP2 (NordCML11) (Nordic CML Study Group): Persistence of major molecular remission (MR3) in chronic myeloid leukemia after a second stop of TKI treatment in patients who failed an initial stop attempt. DASTOP2

Principal investigator: Satu Mustjoki
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


CLL – Chronic lymphatic leukemia

ASSURE: Single-Arm Multicenter Study of Acalabrutinib (ACP-196) in Subjects With Chronic Lymphocytic Leukemia.

Principal investigator: Vesa Lindström
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


CJBH492A12101: Open-label Study of JBH492 in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin’s Lymphoma (NHL)

Not yet active, not yet recruiting.

Principal investigator: Vesa Lindström
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


MDS

STIMULUS, CMBG453B12301: A Randomized, Double-blind, Placebo-controlled Phase III Multi-center Study of Azacitidine With or Without MBG453 for the Treatment of Patients With Intermediate, High or Very High Risk Myelodysplastic Syndrome (MDS) as Per IPSS-R, or Chronic Myelomonocytic Leukemia-2 (CMML-2)

Principal investigator: Mika Kontro
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


Myeloma

CC-92480-MM-001: Open-label study to assess the safety, pharmacokinetics and preliminary efficacy of CC-92480 in combination with dexamethasone in subjects with relapsed and refractory multiple myeloma.

Principal investigator: Pekka Anttila
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


ARROW2: Open-label Study Comparing Once-weekly vs Twice-weekly Carfilzomib in Combination With Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma.

Not yet active, not yet recruiting.

Principal investigator: Pekka Anttila
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center


Sickle Cell Disease

STAND: A Phase III, Multicenter, Randomized, Double-blind Study to Assess Efficacy and Safety of Crizanlizumab, With or Without Hydroxyurea/ Hydroxycarbamide Therapy, in Adolescent and Adult Sickle Cell Disease Patients With Vaso-Occlusive Crises (STAND)

Principal investigator: Ulla Wartiovaara-Kautto
HUS Helsinki University Hospital, Comprehensive Cancer Center

Contact information: HUS Helsinki University Hospital, Comprehensive Cancer Center

 

Pediatric clinical trials

ALL – ACUTE LYMPHOPLASTIC LEUKEMIA

ALLTogether: Treatment Protocol for Children 1- 17 years and young adults 18-45 years with Acute Lymphoblastic Leukemia

Treatment protocol for children 1-17 years  and young adults 18-45 years with acute lymphoblastic leukemia.

Principal investigator: Mervi Taskinen
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital


ALL  – ACUTE LYMPHOPLASTIC LEUKEMIA

TEAM: A phase I-II study of 6-Thioguanine in Combination with Methotrexate and 6-Mercaptopurine during maintenance 2 therapy of childhood, adolescent and adult Acute Lymphoblastic Leukemia

Principal investigator: Jukka Kanerva
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital


ALL relapsed – ACUTE LYMPHOPLASTIC LEUKEMIA

InReALL SR 2010: International Study for Treatment of Standard Risk Childhood Relapsed ALL 2010; A randomized Phase III Study Conducted by the Resistant Disease Committee of the International BFM Study Group

Principal investigator: Päivi Lähteenmäki Turku, Mervi Taskinen HUS
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital


INTERFANT ALL – ACUTE LYMPHOBLASTIC LEUKEMIA

INTERFANT-06: International collaborative treatment protocol for infants under one year with acute lymphoblastic or biphenotypic leukemia

Principal investigator: Olli Lohi Tampere, Kirsi Jahnukainen HUS
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital


AML – ACUTE MYELOID LEUKEMIA

Research study for treatment of children and adolescents with acute myeloid leukaemia 0-18 years, NOPHO-DBH AML 2012 Protocol

Drug study of acute myeloid AML leukemia in children and adolescents NOPHO-DBH 2012.

Principal investigator: Kirsi Jahnukainen
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital


ALL/FORUM – ACUTE LYMPHOPLASTIC LEUKEMIA

ALL SCTped 2012 FORUM: Allogeneic Stem Cell Transplantation in Children and Adolescents with Acute Lymphoblastic Leukaemia

Principal investigator: Kim Vettenranta
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital


EWING relapsed SARCOMA

rEECur: International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma

International Randomized Controlled Study of New or Primarily Refractory Ewining Sarcoma Chemotherapy

Principal investigator: Jukka Kanerva
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital


B-NHL LYMPHOMA

B-NHL 2013: Treatment protocol of the NHL-BFM and the NOPHO study groups for mature aggressive B-cell lymphoma and leukemia in children and adolescents

European Program for the Treatment and Research of Mature B-Cell Lymphoma in Childhood and Adolescence and Burkitt’s Leukemia

Principal investigator: Pasi Huttunen
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital


NHL LYMPHOMA

Central nervous system involvement in non-Hodgin´s lymphoma among children and adolescents

Principal investigator: Kaisa Vepsäläinen Kuopio, Pasi Huttunen HUS
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital


MEDULLOBLASTOMA LR ja SR

SIOP PNET 5 MEDULLOBLASTOOMA: An international prospective study on clinically standard-risk Medulloblastoma in children older than
3 to 5 years with low-risk biological profile (PNET 5 MB – LR) or average-risk biological profile (PNET 5 MB -SR), SIOP PNET 5 Medulloblastoma

Principal investigator: Virve Pentikäinen
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital


HR NBL NEUROBLASTOMA

HR-NBL-1.8 / SIOPEN: High risk neuroblastoma study 1.8 of Siop-Europe (Siopen)

Principal investigator: Kim Vettenranta
HUS Helsinki University Hospital, Comprehensive Cancer Center, Childern’s Hospital