Regional cancer centers jointly start new national seminar series,
the FICAN seminars.
The first speaker will be the FICAN research professor Matti Nykter
Faculty of Medicine and Health Technology, Tampere University
Title: Epigenetic and transcriptomic drivers of treatment resistance in prostate cancer
The seminar is organized by FICAN Mid (Sisä-Suomen syöpäkeskus in Finnish) and it will be held remotely.
Teams link: Click here to join the seminar
Abstract: Prostate cancer is a major global health burden with highly heterogeneous paths for disease progression. Role of AR as a main genomic determinant of treatment resistance is well established. Yet, heterogeneous mechanisms that contribute to disease progressions and treatment resistance are not well understood, hindering clinical management of the disease. In my talk, I will focus on our recent work on epigenetic and transcriptomic mechanisms to address these challenges.
We have recently characterized alterations in prostate cancer epigenome over the disease progression and gained insight into the impact of various genomic aberrations at the level of gene regulatory mechanisms. These studies have identified possible targets for development of new therapeutic approaches, where instead of targeting the molecules directly, epigenetic drugs could be targeted on cancer associated regulatory elements acquired, for example through enhancer hijacking. By combining single cell sequencing at transcriptomic and epigenetic levels, we uncovered and characterized treatment resistant subpopulations of cancer cells from prostate cancer cells. With spatial transcriptomics and bulk sequencing data from tumor tissue samples we demonstrated that expression signature of these cells is present in untreated primary samples and is predictive of treatment outcome both in primary and late stage disease.
Taken together, we are starting to gain understanding on the emergence of treatment resistance and disease progression at the level of epigenetic and transcriptomic regulation, tumor tissue organization and microenvironment in the context of the evolutionary history of the tumors.
More information: Computational Biology | We are part of Academy of Finland Center of Excellence in Tumor Genetics | Tampere Universities (tuni.fi)